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What is Squalane?

Emollient oil

Squalane is a saturated hydrocarbon oil, made today mostly from sugarcane or olive. Formulators use it as an emollient, the part of a formula that stays on the surface and gives a texture its slip. Because it is saturated it does not go rancid the way many plant oils do, so it works in products meant to sit on a shelf for a long time.

What can you expect from it?

  • An oil that leaves skin smooth and soft.

What won't it do?

Claims you often see, and what is actually true.

  • It isn't the same as your skin's own oil.

    Squalane is what your skin already makes, or restores your skin's own lipid

  • It isn't proven to hydrate on its own.

    Squalane hydrates skin or reduces water loss, with clinical proof

  • It isn't shown to fight aging on skin.

    Squalane is an antioxidant, anti-inflammatory or antiaging active

  • It won't smooth wrinkles by itself.

    Squalane itself smooths wrinkles

  • It doesn't push actives deeper.

    Squalane drives actives deeper into skin

  • It isn't proven non-comedogenic.

    Squalane is non-comedogenic, or has a specific comedogenicity rating

Anything to watch out for?

  • A safety panel found it safe as used.
  • There is no allergy or irritation test specific to squalane yet.

Some products' ingredient lists mark this ingredient as below. If a mark's reason fits your skin, it is the ingredient to weigh in those products.

This ingredient is on pore-clogging ingredient lists, which matters most for skin that breaks out easily.
Marked this way on 9 products.

Each mark comes from matching the product's full ingredient list against lists for fragrance, labeled fragrance allergens, drying alcohols, essential oils, fungal acne, pore clogging, and pregnancy caution.

Which products feature it?

84 of the 2320 products we've checked feature this as a key ingredient. Products that disclose a concentration or list it near the top of the ingredient list come first.

Showing 1 to 12.

  • It's registered in Korea as a functional cosmetic for wrinkle improvement.

    Key: Squalane (#3 on the ingredient list · 10%), Panthenol 7%, Madecassoside 0.2%

    8 claims, summarized
    You can expect:
    softer-looking fine lines
    Only partly backed:
    better hydration · better barrier support
    Don't count on:
    a smoother skin texture
    See each claim

    claims, checked

    • Completed functional cosmetic review (or reporting) for wrinkle improvement under the Cosmetics Act.backed by evidence
    • Formulated with 4-fold cica including D-Panthenol 7%, Squalane 10%, and Madecassoside 0.2%, and 17 types of amino acids to simultaneously improve moisturization and skin barrier care. Additionally, applied Layer Melt™ technology that turns the cream formulation into an ultra-fine network, designed to allow moisturizing and barrier ingredients to tightly adhere and absorb along skin contours without gaps.partly backed
    • Additionally, formulated with D-Panthenol 7%, Squalane 10%, 4-fold cica, and 17 types of amino acids to simultaneously consider moisture supply and skin barrier care.partly backed
    • Powerful high-concentration synergy improves high-moisture barrier in just 30 minutes.overstated
    • Through human application testing, we confirmed a 265% improvement in skin moisture barrier and a 170% improvement in transepidermal water loss compared to non-applied areas.no supporting source found
    • These moisturizing and barrier care effects were also confirmed in finished product human application testing. When measured 30 minutes after one use of the D-Panthenol cream, skin moisturization improved by 265%, deep skin moisturization by 5.79%, and moisturization up to 20 layers of the stratum corneum also improved by 177%.no supporting source found
    • We also confirmed changes to the skin barrier weakened by dryness. The skin barrier damaged by physical irritation improved by 57.58% compared to the control group, and also improved by 50.32% when compared to the existing panthenol cream. Additionally, we confirmed that keratin lifted by external micro-irritation improved by 99.31% after a single use.no supporting source found
    • In the primary irritation human application test conducted on hypersensitive skin, the skin irritation score was 0.00, resulting in a low-irritation rating, and dermatologist testing was also completed.no supporting source found
  • It's registered in Korea as a functional cosmetic for brightening and wrinkle improvement.

    Key: Squalane (#14 on the ingredient list · 0.8%), Niacinamide, Adenosine

    40 claims, summarized
    You can expect:
    less visible dark spots · softer-looking fine lines
    Only partly backed:
    better hydration (amount unknown) · calmer skin
    Don't count on:
    better barrier support
    See each claim

    claims, checked

    • Contains 0.8% plant-derived squalanebacked by evidence
    • In a human application test conducted at p&k Skin Clinical Research Center on 31 subjects with sensitive skin, it was judged non-irritating with a skin irritation index of 0.00 even after 24 hours of usebacked by evidence
    • No adverse reactions in all study participantsbacked by evidence
    • In the test results, all 20 participants showed significantly higher moisture content (p<0.05) at the site applied with Neobea Cream Mist than the non-applied sitebacked by evidence
    • Dual-functional cosmetic for skin whitening and wrinkle improvementbacked by evidence
    • Helps with skin whitening. Helps improve skin wrinkles.backed by evidence
    • A high-moisture mist that keeps skin moist and radiantplausible, not tested
    • A cream mist that locks in moisture right after showerplausible, not tested
    • First moisture that wraps gently and hydrates from the insideplausible, not tested
    • A layering routine that makes the outside smooth and the inside moist, restoring skin's natural radiance and moistureplausible, not tested
    • A refreshing finish that is not suffocating even when sprayed multiple timesplausible, not tested
    • Layering it adds natural glow and deep moistureplausible, not tested
    • A plant-based moisturizing ingredient similar to human sebum forms a natural protective film on the skin.plausible, not tested
    • The fine spray pump applies the nourishing formulation evenly and softly to the skin without clumpingplausible, not tested
    • Hyaluronic acid and squalane hydrate from deep in the skin, forming a moisture feel that penetrates tightly to the inner layers without staying on the surfacepartly backed
    • Even sensitive skin can use it daily with peace of mindpartly backed
    • Forms a thin moisture film on the skin surface to prevent water loss and keep the inside moist for a long timepartly backed
    • The patented combination allows even sensitive skin to feel safepartly backed
    • The gentle formulation allows sensitive skin to use it comfortably every daypartly backed
    • It achieves both soothing and moisturizing at once, maintaining balanced skin conditionpartly backed
    • Special inner moisture proven clinicallypartly backed
    • Scientific hydration that reaches moisture to 10 layers inside the skinpartly backed
    • Maximum 547.4% moisture increasepartly backed
    • This moisturizing effect was maintained up to 10 layers deep in the skin and confirmed without adverse reactions in all participantspartly backed
    • Neobea Cream Mist was born from the idea of a new moisturizing layering that can fundamentally improve internal skin dryness even when lightly sprayedno supporting source found
    • The patented soothing formula and panthenol quickly calm irritated skinno supporting source found
    • Serves as a moisture-locking base that improves absorption of subsequent skincare stepsno supporting source found
    • Restores the oil-moisture balance by replenishing squalane, which declines rapidly after age 25.no supporting source found
    • Sorbitol, which attracts moisture, and panthenol, which reinforces the skin barrier, work together to quickly soothe sensitive skinno supporting source found
    • As a patented raw material that fully preserves the ultra-low molecular structure of 379 Da, it is rapidly absorbed deep into the skin, filling it with dense moisture and fundamentally improving internal drynessno supporting source found
    • Designed with patented ingredients that effectively reduce skin irritation and prevent moisture lossno supporting source found
    • It maintains skin comfort even with continued use and provides superior calming care.no supporting source found
    • Dermatologist testing completedno supporting source found
    • Quick soothing with patented DoubleCalm (Sorbitol + Panthenol)no supporting source found
    • We conducted dozens of pump tests and studies to find the optimal spray angle that fits various facial structuresno supporting source found
    • HyalSeed (Hyaluronic Acid Complex) [Patented Ingredient]no supporting source found
    • What skin really wants is light yet deeply penetrating moisturenothing specific to check
    • #InnerMoistureMist #BeforeSkincareMist #MoistureLocknothing specific to check
    • Finding the balance of moisturizing, beyond which is as bad as falling shortnothing specific to check
    • A cream mist that has evolved one step furthernothing specific to check
  • It's made for calmer, clearer-looking skin.

    Key: Squalane (#1 on the ingredient list), Melaleuca Alternifolia (Tea Tree) Leaf Oil 2%, Hydroxypinacolone Retinoate

    24 claims, summarized
    Only partly backed:
    calmer skin (amount unknown) · less visible pores · clearer-looking skin (amount unknown) · a smoother skin texture
    See each claim

    claims, checked

    • Extreme Calming Tea Tree Oil was designed by adding 4th generation retinol (HPR), bakuchiol, and squalane to tea tree oil for reliable trouble soothing.backed by evidence
    • Tea tree oil has a powerful soothing effect.plausible, not tested
    • A daily soothing oil that can be used on the entire face every day.plausible, not tested
    • Not spot care, but full-face care is possible.plausible, not tested
    • Tea tree leaf oil: Soothing sensitive skin, trouble prevention careplausible, not tested
    • A natural oil rich in 4-terpineol that shows high effectiveness in relieving sensitive skin caused by troubleplausible, not tested
    • A representative plant-derived ingredient with efficacy similar to retinol that acts gently on the skin and helps sebum control and pore improvementplausible, not tested
    • 4th generation retinol: Promotes turnoverplausible, not tested
    • High-function vitamin A with reduced irritation compared to conventional retinolplausible, not tested
    • An ingredient with a structure similar to the human skin lipid squalene that has high skin affinity and helps absorption of high-function ingredientsplausible, not tested
    • A non-sticky, fresh finish suited to a daily soothing routineplausible, not tested
    • Designed with a pumping dispenser that minimizes air contact.plausible, not tested
    • Gyeol House's Extreme Calming Tea Tree Oil goes beyond soothing trouble to manage sebum, pores, and dead skin cells.partly backed
    • Sebum amount 51% reductionpartly backed
    • Pore distribution 50% reduction, pore area 21% reduction, pore depth 22% reductionpartly backed
    • Skin roughness 11.45% improvementpartly backed
    • Suitability evaluation test for acne-prone skin completedpartly backed
    • As the name suggests, extreme soothing.overstated
    • Gentle vitamin A usable every dayoverstated
    • Extreme Calming Tea Tree Oil's efficacy and stability have been proven through clinical trials.overstated
    • All of this without irritation, gently.no supporting source found
    • Trouble area redness 6.79% improvementno supporting source found
    • Stabilizes skin condition so that trouble does not recur.no supporting source found
    • Rather than being a one-off response, it proposes a daily routine that cares for trouble from multiple angles and changes the skin environment itself.nothing specific to check
  • It's made for firmer skin and less visible pores.

    Key: Squalane (#1 on the ingredient list), Retinol 0.5%, Tocopherol

    53 claims, summarized
    Only partly backed:
    firmer skin · less visible pores (amount unknown) · better hydration (amount unknown)
    Don't count on:
    softer-looking fine lines · calmer skin · clearer-looking skin
    See each claim

    claims, checked

    • Powerful skin slow-aging effect in a single dropplausible, not tested
    • Lightly absorbs for a shimmering silky oil formulaplausible, not tested
    • + Firmness & Smooth + Improve radianceplausible, not tested
    • Retinol #PoreCare Normalizes slowed cell turnover and makes skin smooth!plausible, not tested
    • An oil formula with a light feelplausible, not tested
    • A watery formula that spreads instantly on contact for a dewy feel!plausible, not tested
    • Fast absorption and a light finish make next-step care easy.plausible, not tested
    • Perfect-match synergistic ingredients deliver smooth glow and hydrationplausible, not tested
    • Super Vitamin E + Squalanepartly backed
    • Skin aging index improvement, pore improvementpartly backed
    • Lifting carepartly backed
    • Inner elasticity and outer elasticity carepartly backed
    • Begin a different level of slow-aging with pure retinol 0.5%partly backed
    • Retinol for the experienced that delivers pure retinol 0.5% special slow-aging effectpartly backed
    • Squalane #MoistureCare Protects the skin from external irritants / harmful ingredients / moisturizespartly backed
    • High-concentration formulation of pure retinol 0.5%, more effective than retinol derivativespartly backed
    • Improvement effect of *skin aging index by 4% confirmed through human application testpartly backed
    • Eye area skin angle 12.2%partly backed
    • Cheek area skin angle 10.3%partly backed
    • Mouth corner skin angle 13.7%partly backed
    • Jawline skin angle 13.5%partly backed
    • More compact and dense, smooth and firm, texture & elasticity carepartly backed
    • Soft to the touch, *surface elasticity +16% increasepartly backed
    • Firming from within, *inner elasticity +13% increasepartly backed
    • #HighStrengthRetinol Special Slow-Aging (Night Intensive)partly backed
    • Pure retinol 0.5%, Super Vitamin E, plant-derived squalanepartly backed
    • The Slow-Aging secret of Cosrx Retinol that thoroughly cares for sagging / elasticity / poresoverstated
    • Clinically proven skin aging index improvement effectoverstated
    • The Slow-Aging secret of Cosrx Retinol that thoroughly cares for sagging / elasticity / pores, the main culprits of skin agingoverstated
    • The daily anti-aging oil that the reviews speak foroverstated
    • Satisfaction with skin changes over approximately 4 weeks, experienced by 100% of consumers without exaggerationoverstated
    • 100% felt that fine lines across the face were reducedoverstated
    • 100% felt their skin became elastic and liftedoverstated
    • 100% felt their skin texture became smooth, moist, and softeroverstated
    • 1st place Beauty AWARDS 2022 Wrinkle Functional - Creamno supporting source found
    • 2位 K-COSME AWARDS 2023 乳液クリーム Qoo10no supporting source found
    • BEST OF Forbes VETTED 2024no supporting source found
    • Wrinkle improvement functional productno supporting source found
    • Refreshing retinol oil that relieves burdenno supporting source found
    • One-step synergy care that completes radiance, hydration, and elasticityno supporting source found
    • Teukoteurienol #ElasticityCare Synergy with retinol for an elasticity-enhancing effectno supporting source found
    • No.1 on Hwahae just 3 months after launch!no supporting source found
    • 1st place Beauty AWARDS Best New Product 2022 H2 Face Oil categoryno supporting source found
    • In just 2 weeks! Improves large, enlarged poresno supporting source found
    • Soothes skin troubles and marks at once for smooth, clean skin careno supporting source found
    • Refreshingly erases *the 4 major trouble concernsno supporting source found
    • Pore volume -21.95%no supporting source found
    • Pore area -20.91%no supporting source found
    • Pore count -29.48%no supporting source found
    • Pore depth -33.34%no supporting source found
    • Completed 2 skin irritation tests; safe for sensitive skinno supporting source found
    • Skin primary irritation test completedno supporting source found
    • Primary irritation test completed for sensitive skinno supporting source found
  • Key: Squalane (#2 on the ingredient list), Hyaluronic Acid, Adenosine

    2 claims, summarized
    Don't count on:
    better hydration
    See each claim

    claims, checked

    • S.NATURE Aqua Squalane Moisture Cream combines purity found in nature with science to deliver clear and moist hydration to the skin every day.overstated
    • Cleanly and smartly, experience true beauty.nothing specific to check
  • Key: Squalane (#2 on the ingredient list), Jojoba Seed Oil, Limnanthes Alba (Meadowfoam) Seed Oil

    1 claim checked

    claims, checked

    • A moisturizing oil of a different texture that rescues parched skinplausible, not tested
  • Product photo of 마데카소사이드 흔적 리페어 더마 크림

    Mediheal

    마데카소사이드 흔적 리페어 더마 크림 (Korean)This brand publishes no English name for this product. The name above is as printed in Korean.

    It's registered in Korea as a functional cosmetic for brightening.

    Key: Squalane (#3 on the ingredient list), Madecassoside, Niacinamide

    4 claims, summarized
    You can expect:
    less visible dark spots
    Only partly backed:
    better hydration (amount unknown) · better barrier support (amount unknown)
    See each claim

    claims, checked

    • Madecassoside, Ceramidebacked by evidence
    • Whitening functional cosmeticsbacked by evidence
    • Sensitive skin | Dry skinplausible, not tested
    • From scar care to moisture barrier strengthening, high-purity Madecassoside Derma Repair Creampartly backed
  • Key: Squalane (#3 on the ingredient list), Ethylhexyl Palmitate, Sorbeth-30 Tetraoleate

    5 claims checked

    claims, checked

    • Transforms into a soft milky texture upon contact with water, rinsing clean without heavy residue.plausible, not tested
    • Helps dissolve daily makeup, excess sebum, and impurities while maintaining a smooth, hydrated feel.plausible, not tested
    • Formulated with 5% Olive Squalane and a blend of Jojoba, Sunflower, and Grape Seed Oils to help support skin’s natural moisture while cleansing.partly backed
    • Designed to cleanse thoroughly without stripping.overstated
    • Gentle enough for everyday use, including dry and sensitive skin types. Ideal as the first step in a double cleansing routineoverstated
  • It's made for better hydration and a smoother skin texture.

    Key: Squalane (#3 on the ingredient list), Jojoba Seed Oil 11.2%, Hyaluronic Acid

    24 claims, summarized
    Only partly backed:
    better hydration (amount unknown) · a smoother skin texture
    See each claim

    claims, checked

    • Contains 112,000ppm of premium golden jojoba oilbacked by evidence
    • Oil 2 : Moisture 8 Two-Layer Designplausible, not tested
    • First essence mist that first captures moisture escaping right after cleansingplausible, not tested
    • Moisture barrier resembling skin, jojoba oil & squalaneplausible, not tested
    • A plant oil with components similar to squalene in skin lipids, offering high skin affinity and prevention of moisture loss.plausible, not tested
    • Glacier glycoprotein that lives in extreme cold has the ability to embrace moisture in dry environments, aiding in moisture retention.plausible, not tested
    • Oil & moisture two-layer mist, helps with these skin concerns.plausible, not tested
    • Oil & moisture particles that settle evenly over the entire faceplausible, not tested
    • PHA, a low-irritation exfoliating ingredient that even sensitive skin can use, removes old dead skin cells and helps improve skin texture.plausible, not tested
    • Moisture quickly fills in with no room for dryness.plausible, not tested
    • Thinly layers moisturizing ingredients to intensively care for inner dryness.plausible, not tested
    • Hydration Jojoba Essence Mist sprays moisture and oil in fine particles to slow moisture evaporation and reduce dryness right after cleansing.partly backed
    • Skin moisture 45.36% increasepartly backed
    • Transepidermal water loss 6.48% decreasepartly backed
    • 8 types of hyaluronic acid of different sizes supply moisture layer by layer from the skin's surface to its inner layers.partly backed
    • Fills moisture and prevents evaporation to prevent dryness.partly backed
    • Part 4. Contains PHA 1.5%partly backed
    • It has a structure most similar to human skin lipids and forms a lipid membrane on the skin to prevent moisture evaporation.overstated
    • 0.00% skin irritation indexno supporting source found
    • Suitability for use on sensitive skin Yes / Nono supporting source found
    • COSMOS certified organic jojoba seed oilno supporting source found
    • Uses an extraction technique that preserves jojoba's nutrients to the maximum.no supporting source found
    • 0-step hydration completed by sprayingnothing specific to check
    • Moisturizing quality that changes from the start with 0-step care.nothing specific to check
  • Product photo of 그린 콜라겐 아이크림 포 페이스

    LEADERS

    그린 콜라겐 아이크림 포 페이스 (Korean)This brand publishes no English name for this product. The name above is as printed in Korean.

    It's registered in Korea as a functional cosmetic for wrinkle improvement.

    Key: Squalane (#4 on the ingredient list), Adenosine, Collagen

    11 claims, summarized
    You can expect:
    softer-looking fine lines
    Only partly backed:
    firmer skin
    See each claim

    claims, checked

    • Functional for wrinkle improvementbacked by evidence
    • Intensive elasticity care from face to neckplausible, not tested
    • You can apply it not only to the eye area but to all areas where wrinkles are a concernplausible, not tested
    • Even though it's a high-concentration product, it has no stickiness, so on days when the skin is especially rough, you can apply it to your entire faceplausible, not tested
    • High-efficacy eye cream that improves wrinkles and elasticitypartly backed
    • Pea peptide that cares for elasticitypartly backed
    • Eye cream that intensively manages wrinkles with a plant-based formulapartly backed
    • 30ml 4-pack high-concentration eye cream for wrinkles & elasticityoverstated
    • Phyto collagen extracted from plantsno supporting source found
    • Vegan formula for sensitive skinno supporting source found
    • Applies smoothly and gently without irritation to sensitive eye areasno supporting source found
  • It's made for better hydration and better barrier support.

    Key: Squalane (#4 on the ingredient list), Hydroxypropyl Bispalmitamide MEA, PCA

    6 claims, summarized
    Only partly backed:
    better hydration (amount unknown) · better barrier support (amount unknown)
    Tests passed:
    dermatologist check
    See each claim

    claims, checked

    • Dermatology test completed, suitability for acne-prone skin test completed, allergy test completedbacked by evidence
    • Moisture-Charging Essence Within the Skin Barrierplausible, not tested
    • A skin barrier moisturizing essence that fills delicate skin with 30 types of moisture nutrientspartly backed
    • 99% are satisfied with spreadability, 95% are satisfied with moisture feel, 95% are satisfied with absorption, 2020 October Hwahae survey group of 292 peoplepartly backed
    • With DermaON capsule moisturizing technology, it implements a lipid structure of ceramide, cholesterol, and fatty acids similar to that of the skin, enhancing moisture delivery and strengthening the moisture barrier.partly backed
    • #MoistureChargingWithinBarriernothing specific to check

Are the claims about it backed up?

We checked each claim that features this ingredient. Open the list below to see the result for each one.

See the results by claim
ResultClaims
backed by evidence4 of 45
plausible, not tested7 of 45
partly backed23 of 45
overstated6 of 45
no supporting source found5 of 45

These are counts of claims, not products. One product can name the same ingredient in several claims, and we checked each one on its own.

Which articles cover it?

Posts on this site that take this ingredient as their subject.

Sources

We summarized the published studies and public records listed below, each with its DOI or PubMed number. Findings about treating medical conditions are outside what a cosmetics page covers, so we left them out.

What can you expect from it?

  • An oil that leaves skin smooth and soft.

    Squalane sits in a moisturizer already on sale as the ingredient that smooths and softens. But that trial tested the whole multi ingredient product, so it says nothing about squalane's own share.

    A comparison of one multi ingredient moisturizer against another, with squalane present in both arms.

    Squalane appears as the emollient component of a marketed moisturizer whose full formula (occlusive dimethicone; humectants glycerin, saccharide, butylene glycol and hyaluronic acid; emollients shea butter and squalane) was tested clinically.

    Sources: 6

What won't it do?

  • It isn't the same as your skin's own oil.

    What skin itself makes is squalene, and squalane is that molecule altered so it keeps. It is chosen for cosmetics precisely because it is not the form skin makes, so identical to your own oil does not hold.

    Not a test result but a difference in chemistry: the molecule making up 13% of skin's own surface oil is squalene.

    Contradicted by the chemistry in the record.

    The molecule present in human sebum at 13% is squalene, the polyunsaturated compound, and squalane is its saturated derivative.

    Sources: 2

  • It isn't proven to hydrate on its own.

    The hydrating line comes from a review that counts squalene and squalane as one and rests on animals and on work outside skin. The one human trial here tested whole multi ingredient products, so no squalane specific water gain can be pulled out of it.

    No study here measured skin water, or how much water escapes through skin, with squalane as the only thing varied.

    The one review that reports skin hydrating activity attributes it to squalene and squalane together and places the evidence in animal models and in vitro environments, which is not a human skin claim.

    Sources: 2

  • It isn't shown to fight aging on skin.

    Those results came from cultured cells in a dish rather than from skin, at concentrations used for cell work. They were read in cells exposed to UVA, so they do not carry over to skin someone applied it to.

    Cultured cells taken from the deeper layer of skin rather than skin itself, at 0.005 to 0.015%.

    These findings exist but are in cultured cells.

  • It won't smooth wrinkles by itself.

    In the wrinkle trial the squalane cream was the comparison arm, and the cream with an added active did better than it at week 8. Squalane was the side that lost, not the side that won.

    An 8 week trial in 23 women with one cream on each side of the face, nobody involved knowing which side was which.

    Positively anchored against.

    In an 8 week randomized, matched pair, double blind split face trial in 23 Japanese women, squalane blended cream was the placebo arm, and the fullerene-C60 in squalane cream was significantly more effective than that placebo at week 8.

    Sources: 5

  • It doesn't push actives deeper.

    Adding squalane lowered how much of the compounds formulated with it passed through skin. It holds them in the skin rather than pushing them deeper.

    One study on human skin outside the body, measuring how much passed through the skin from an emulsion placed on it.

    Contradicted in the one delivery study located.

    Adding squalane lowered the permeability coefficients of every polyphenol measured, increasing skin retention rather than transdermal passage.

    Sources: 3

  • It isn't proven non-comedogenic.

    No study was found on whether squalane blocks pores. The ratings that circulate widely trace back to nothing in this record, so they are not repeated.

    The searches turned up only one unrelated 1974 rat paper.

    No evidence located.

    Widely circulated comedogenic ratings are not traceable to any source in this corpus and are not repeated here.

Citations

  1. 1
    Fiume M, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Heldreth B. Squalane and Squalene. Int J Toxicol. 2023;42(3 Suppl):107S-109S.DOI 10.1177/10915818231204276PMID 37752766
  2. 2
    Kim SK, Karadeniz F. Biological importance and applications of squalene and squalane. Adv Food Nutr Res. 2012;65:223-233.DOI 10.1016/B978-0-12-416003-3.00014-7PMID 22361190
  3. 3
    Oliveira ALS, Valente D, Moreira HR, Pintado M, Costa P. Effect of squalane-based emulsion on polyphenols skin penetration: Ex vivo skin study. Colloids Surf B Biointerfaces. 2022;218:112779.DOI 10.1016/j.colsurfb.2022.112779PMID 35994992
  4. 4
    Wolosik K, Chalecka M, Gasiewska G, Palka J, Surazynski A. Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast. Molecules. 2025;30(9):1964.DOI 10.3390/molecules30091964PMID 40363772
  5. 5
    Kato S, Taira H, Aoshima H, Saitoh Y, Miwa N. Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics. J Nanosci Nanotechnol. 2010;10(10):6769-6774.DOI 10.1166/jnn.2010.3053PMID 21137794
  6. 6
    Prakoeswa CRS, Damayanti, Anggraeni S, Umborowati MA, Sari M, Hendaria MP, Thahir TF. The Role of Moisturizer Containing Anti-inflammatory on Skin Hydration in Mild-Moderate Atopic Dermatitis Patients. Dermatol Res Pract. 2024;2024:3586393.DOI 10.1155/drp/3586393PMID 39741562

What each point on this page rests on, with full citations.